Genome Engineering and Synthetic Biology at the Genome Institute of Singapore
Life can now be programmed to molecular precision. I will share how we are taking these engineering advances from molecule to human. On the smallest molecular levels, I will share our recent work in the development of new genome editors, including one of the first C-to-G base editors that precisely convert single nucleotides within mammalian cells. I will also share multiple exciting developments in high-throughput protein and viral assay and engineering, both in terms of new methodology and how these technology platforms confer desired functionality to the newly engineered assets. Moving towards cells and whole mammals, I will share our work and goals in genetically engineering cells, human 3D organoids, and large animals, both for therapeutic development and for dissecting novel biological insights. Finally, we will touch on our near-term vision for synthetic biology research and tech development in our group and how we envision working more closely with you.