Supported by National Research Foundation



Synthetic biology is a maturing scientific discipline that combines science and engineering in order to design and build new biological parts, devices and systems. Synthetic biology offers enormous opportunities to benefit society with promising applications in areas such as energy, healthcare and the environment. Launched in September 2016, the Singapore Consortium for Synthetic Biology, SINERGY aims to consolidate Singapore’s capabilities in synthetic biology and harness synergies across industry sectors to create a vibrant and globally connected bio-based economy in Singapore. Efforts to foster interactions and co-development between the industry, universities and research institutes will encourage user-inspired research, augment manpower development, as well as speed up the translation of expertise in synthetic biology for industry applications. SINERGY is supported by the National Research Foundation and hosted at the National University of Singapore.


  • Upgrade industry technological abilities through active engagement and co-development among industry, universities and research institutes
  • Harness synergies across R&D collaborative projects
  • Facilitate manpower deployment from institutes of higher learning to industries
  • Provide a one-stop, go-to national resource centre for companies and members

Key areas of interest

  • Advanced Manufacturing for Specialty Chemicals
  • Protein and Enzyme Engineering
  • Biosensors and Cell-Free Systems
  • Biomimetics
  • Synthetic Genomics
  • Proprietary Strain Construction and Optimization


NUS Synthetic Biology Foundry

NUS Synthetic Biology Foundry represents a hallmark of synthetic biology research in driving foundational science towards translational clinical and industrial biotechnology applications. Equipped with state-of-the-art robotic system that is interfaced with various high throughput analytical instruments, the Foundry enables systematic (re)designing, building, testing and learning of synthetic biological systems on a highly efficient, automated manufacturing platform. By fostering advanced research through international collaborations, the Foundry aims to become a central hub for cutting-edge synthetic biology research in Asia.


Gas Chromatography
Mass Spectrometer

Ultra-High Performance Liquid
Chromatography System

Quadrupole Time-of-Flight
Liquid Chromatography/
Mass Spectrometry System

Fluorescence Activated
Cell Sorter


Real-Time Polymerase
Chain Reaction
(PCR) System



For information on facility usage,

please contact us.


Industry Members

Academic Members


The Consortium membership is open to companies that:

  • Are actively involved in synthetic biology-related manufacturing, design or R&D
  • Apply synthetic biology approaches in their product or manufacturing processes
  • Provide technologies, products or services that support synthetic biology applications
                                                                            Non Start-Up Company Start-up Company
Membership Entrance Fee S$10,000 S$1,000 (e)
Annual Membership Fees S$1,000 S$1,000 (e)


(a) The Membership Fee is inclusive of Goods and Services Tax.

(b) The Membership Fee shall be payable in advance of the applicable membership year within thirty (30) days from the date of invoice issued by NUS.

(c) The effective date of membership is 1st January, 1st May, or 1st September of year of application, as determined in accordance with Sections 3 and 4 of the Membership Application Form, and membership is effective for a whole calendar year.

(d) Membership is renewable on an annual basis, in advance, and shall be effective from 1st January, 1st May, or 1st September of the following year, according to the date of membership registration.

(e) Start-ups which are in their first 5 years of incorporation and with revenue under S$ 1 million, can qualify for waiver of the Membership Fee.

For information on membership fees,

please contact us.



Synthetic biology: opportunities, challenges, and future prospects in Africa

Synbio Africa is a forum for researchers, students, citizen scientists, policy makers and the public at large to convene and develop successful pathways for the propagation of synthetic biology technologies, products, and services throughout Africa.
Register for the event.
Synthetic Biology in Africa

Synthetic biology: opportunities, challenges, and future prospects in Africa

Synbio Africa is a forum for researchers, students, citizen scientists, policy makers and the public at large to convene and develop successful pathways for the propagation of synthetic biology technologies, products, and services throughout Africa.
Register for the event.
Synthetic Biology in Africa

CRISPR complex IP landscape: how it affects research and innovation

The discovery of the CRISPR system and its use as a precision editing tool opened a new era in bioengineering. The precise molecular scissors allowed the bioengineering of cells and...
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European Synthetic Biology Society

Synthetic Biology for Expanding the Chemical Landscape of Living Cells

Fluorine is a key element in the synthesis of molecules broadly used in medicine, agriculture and materials. Addition of fluorine to organic structures represents a unique strategy for tuning molecular...
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Dr Pablo Iván Nikel

Biotech Startup 101: IP Management

Intellectual property is the lifeblood of the biotechnology industry. With strong patents being critical for biotechnology companies developing innovative solutions. For biotech startups, a well-thought-out patent... Register for the event.
SGINNOVATE & Sinergy Online Event

Across space and time – Spatial and longitudinal analysis of the mouse gut microbiota

The laboratory mouse remains the most widely used model for microbiome research and yet some facets of the mouse microbiome remain poorly investigated. This concerns particularly the cultivation of anaerobic mouse ... Register for the event.
Dr Henning Seedorf

2021 Global Biofoundries Alliance Webinar Series

Our presenters are: Dr Rosalind Le Feuvre Director of Operations, SYNBIOCHEM and Future BRH, Manchester Institute of Biotechnology, UK. Dr. Mark Dörr Head of LARA Platform, Institute for Biochemistry, University...
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GBA Webinar Series

Biofabrication: Introducing Sustainable Biomaterials

Most of the focus of sustainable manufacturing is on reducing the use of disposables and single-use-plastics. However, what if sustainability starts at the production and not the consumption stage?
Register for the event
SGINNOVATE & Sinergy Online Event

Shaping in vitro solid tumor microenvironments models for T cell therapy and drug discovery

Immunotherapy aims to redirect the patient’s immune system to fight against pathology and holds great promise as a novel cancer treatment.
Register for the event.
Dr Andrea Pavesi

GBA Webinar Series 1

Our presenters are: Chueh Loo Poh (Associate Professor) from Engineering Biology Lab, SynCTI, NUS. Esteban Marcellin Saldana (Associate Professor) AIBN, UQ. Please register in advance for this meeting using this...
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GBA Webinar Series

Gaining dynamic control of synthetic biology with a theory-experiment hybrid approach

Feedback control is the key to achieve robust performances for many engineered systems. Although control theory in electronic and mechanical systems are well developed and have been sophisticatedly implemented, control...
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Chelsea Hu

Synthetic Biology in Asia

Meet the Authors: Professor Xiao-Xia Xia – Shanghai Jiao Tong University Assistant Professor Jeong Wook Lee – POTSTECH Moderator: Assistant Professor Adison Wong – Singapore Institute of Technology
Prof Xiao-Xia Xia & Dr Jeong Wook Lee

Engineering synthetic regulatory systems using naturally inspired design principles

We have recently demonstrated that two engineering principles inspired by natural regulatory networks can be used to create new classes of synthetic circuitry in eukaryotic cells: 1) In eukaryotic gene...
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Caleb Bashor

Detection of clinically relevant RNA transcripts using RNA-toehold switch sensors

Tools to rapidly identify RNA transcripts have wide clinical use in areas ranging from viral diagnostics, to microbiome and antibiotic resistance research. This talk will outline the development and progress...
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Melissa Takahashi

Molecular Programming Using De Novo Designed Proteins

The design of DNA primers involves simply writing down the reverse complement of the target sequence, made possible by the modular A-T and G-C base pairing. Such modularity offers great...
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Dr Zibo Chen

Sustainable Bio-Manufacturing in APAC: From Chemicals to Materials [Online Event]

Synthetic biology is the principle of synthesizing DNAs and designing & building genetic elements and circuitry to enhance or repurpose cellular functions. In recent years, advancements in this field have...
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SGINNOVATE & Sinergy Online Event

Protein and Metabolic Engineering As An Enabling Tool For Synthetic Biology

Natural products have been frequently used not only for biomedical purposes but also in the field of biotechnology. But, the availability of these natural products as a pure compounds and...
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Dr Edward Wong

Navigating Singapore’s BioTech Startup Ecosystem [Online Event]

According to the Biotechnology Innovation Organisation, BioTech is “technology based on biology – harness[sing] cellular and biomolecular processes to develop technologies and products that help improve our lives and the...
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SGINNOVATE & Sinergy Online Event

Sex Determination in Agricultural Pest Insects and Genetic Control Strategies

The dipteran Tephritidae family includes dozens of major agricultural pest species, including the mediterranean fruitfly Ceratitis capitata (medfly). The genetic control of these species can be based on the release of sterile males, following their sexing from females.
Giuseppe Saccone

EFI Genomic Enzymology Web Tools ([email protected]): Discovery of Novel Enzymes and Metabolic Pathways

The number of proteins in the UniProt database (>182M sequences in Release 2019_10) is increasing with a doubling time of ~2.5 years; however, ≥50% of the proteins have uncertain, unknown, or incorrect functions. This lecture will describe...
John A. Gerlt

Updates and Applications: Ambient Ionization Mass Spectrometry

Mass spectrometry (MS) is an important analytical technique with high sensitivity and selectivity. However, all known ambient MS ionization methods are significantly hindered by ion suppression that is caused by ion charge competition other than the target molecules.
Morphy Dumlao

Structural evidence for a functional actin cytoskeleton in Asgard archaea

The origin of the eukaryotic cell is unresolved. Metagenomics sequencing recently provided evidence for several potential eukaryotic gene homologs in the Asgard archaea. However, many of these eukaryotic-like sequences are highly divergent and the organisms have yet to be imaged or cultivated, bringing in to question whether these archaea exhibit eukaryotic characteristics.
Robert C. Robinson

In vitro Synthetic Biology – using cell free systems to rapidly access to xenobiotics in a test-tube

Cell-free transcription/translation systems (known as CFPS or TX-TL) have recently been re-evaluated as a promising platform for enabling synthetic biology research and applications. In particular CFPS has been shown to...
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Paul Freemont

Functional Metagenomics: Gene Function Discovery in Uncultivated Bacteria

How do we develop a more thorough understanding of the vast majority of microbes on Earth that have never been successfully cultured? Many of these microbes are known from their...
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Trevor C. Charles

Nanopore analysis of biological molecules and complexes

Nanopore microscopy is a high-throughput, single-molecule technique capable of detecting the shape, structure and chemical properties of individual biomolecules and complexes, including DNA, proteins and viruses. The technique relies on...
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Slaven Garaj

Engineering systemic organ interactions with microfluidics

Human physiology and pathophysiology, such as such as in metabolic diseases and microbiome-host interactions, often involve systemic interactions between multiple tissues. Multi-organ perfusion systems offer the unique opportunity to mimic different physiological systemic interactions...
Yi-Chin Toh

Single Cell Clinical Analysis for Precision Medicine by Using Integrative Microfluidics

Precision medicine refers to giving the right therapeutics, to the right patient, at the right time. In the context of cancer, successful implementation of precision medicine, requires treatment individualization not...
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Chia-Hung Chen

The Importance of Standards, Foundries and Information Systems in BioDesign and Industrial Translation

The seminar will address the role of standards, foundries and information systems in relation to BioDesign and industrial translation. These will be discussed against the background of the  development of...
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Richard I Kitney

Enabling a rapid transition to a global bioeconomy with synthetic biology – opportunities and challenges

Petroleum has played an important role in the social, economic and political history of the world particularly in Singapore. The start of the 20th century, led to an industrial revolution in...
Paul Freemont

Droplet microfluidics: how to do millions of experiments in picoliter volume

Weitz and his group study the physics of soft condensed matter, materials easily deformed by external stresses, electric, magnetic or gravitational fields, and even thermal fluctuations. These materials typically possess structures much larger than...
David A. Weitz

Synthetic small intestines for treating and studying intestinal disease

In recent years, it has become widely accepted that in vitro intestinal models enable improved studies of intestinal function in an ethical and well-controlled manner.
John C. March

“Me? An Entrepreneur?”

To make the world a better place, we need great solutions.  Entrepreneurs around the world have been instrumental in advancing technological processes, disrupting traditional industries and creating impactful change.  Do...
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Brian SH Koh

Genome-wide target specificity of CRISPR RNA-guided base editors

Adenine Base Editors (ABEs), composed of the Cas9 nickase derived from S. pyogenes and engineered adenine deaminases derived from E. coli, enable efficient adenine-to-guanine single-nucleotide conversions in human cells.
Jin-Soo Kim

Metabolic engineering and regulation of the bosynthesis of artemisinin, the most potent anti-malaria compound, in Artemisia annua L.

Artemisinin, an endoperoxide-containing sesquiterpene lactone isolated from Artemisia annua L., is extensively used in treating malaria. The artemisinin-based combination therapy (ACT) is recommended by World Health Organization (WHO) to combat...
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Kexuan TANG

Bio-inspired Electronic Skins

Electronic sensor skins are active area of research for many groups globally due to its potential to enable dramatic changes in how we interact with the digital environment. For example,...
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Benjamin C.K. Tee

Medical applications of innovative mussel protein bioadhesives

Marine mussel adhesion is known to be mediated by adhesive proteins, which are secreted through the mussel byssus and have great potential as biologically and environmentally friendly adhesive biomaterials due...
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Cha Hyung Joon

Design, Construction, and Analysis of a Synthetic Minimal Bacterial Cell

The minimal cell is the hydrogen atom of cellular biology. Such a cell, because of its simplicity and absence of redundancy would be a platform for investigating just what biological components are required for life, and how those parts work together to make a living cell.
Dr John I. Glass

GT (Sialyltransferase and fucosyltransferase) mutagenesis and Metabolic Engineering for the synthesis of 3‘/6‘-SL and 2‘/3-FL from human Milk

Oligosachharides in human milk(HMOs) have various useful biological functions for infant and applications in industry. Among them, sialyllactose(3’/6‘-SL) and fucosyllactose(2‘/3-FL) draw our atttention. To produce these oligosaccharides in large quantity,...
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Kim Byung Gee

Biocatalysis of soybean isoflavonoids using various oxidoreductases: synthesis of hydroxyl-equol derivatives

Soybean plant originated from Manchuria are known to be spread out in world, and the regions from North Korea to Manchuria have the highest diversity of the soybean species worldwide.
Kim Byung Gee

Protein Engineering, the unsung hero of next generation sequencing

Illumina sequencing technology has reduced the cost of genome sequencing from ~$1B two decades ago to ~$1K today..
Dr Sergio Peisajovich

Salivary gland cancers: A rare cancer as a platform for precision medicine

Salivary gland cancer is a rare cancer with various subtypes. Expanding knowledge in genomics shed a new light on the rare cancers - current understanding, future directions ...
Hyunseok Kang

Getting your device onto the Singapore market

This talk provides an introduction to the product registration process by HSA, covering the documentation requirements for the various device risk classifications.
Daniel Yap

Synthetic Biology – a Key Driver of the BioEconomy through BioDesign and Industrial Translation

Synthetic biology/engineering biology is highly disruptive technology that can be applied across a wide range of fields - well beyond the scope of traditional industrial biotechnology. It is seen as a key driver of the BioEconomy and is part...
Richard I Kitney

Rapid acquisition and model-based analysis of cell-free transcription-translation reactions from non-model bacteria

Cell-free transcription/translation systems (known as CFPS or TX-TL) have recently been re-evaluated as a promising platform for enabling synthetic biology research and applications. In particular CFPS has been shown to provide a...
Paul Freemont

From Gene to Activity – Exploiting the Potential of Nestlé Culture Collection

Nestlé boasts a culture collection of more than 3000 food-grade strains (Nestlé Culture Collection, NCC) that has been integrated into an R&D network covering microbiology, fermentation,...
Jeroen Muller

Aberrant Stem/Progenitor Cell Behavior During Aging And Cancer

Adult stem cells, with the unique property of performing self-renewal and multi-lineage differentiation, are essential for maintaining homeostasis and function of various organs in our body, including the hematopoietic system...
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Derrick Ong

Building Complex Protein Functions at the Intersection of Nanofabrication and Synthetic Biology

Proteins are the most versatile among the various biological building blocks. However, the strength of proteins – their versatility and specific interactions – also complicates and hinders their systematic design...
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Wilfred Chen

Biofilm Biology-Informed Biofilm Engineering

Biofilm represents the predominant mode of growth of microorganisms in natural, engineered and medical habitats. Microbial biofilms can be either beneficial or detrimental in different settings. While an enhanced understanding...
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Cao Bin

Innovations in Cell-Free Synthetic Biology

Cell-free transcription-translation systems were originally applied towards in vitro protein production. More recently, synthetic biology is enabling these systems to be used within a systematic design context for prototyping DNA...
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Richard Kelwick

Biotechnology to Help Achieve the UN’s Sustainable Development Goals

We are living in a world that is so rapidly changing with a lot of global risks. To make better state of the world, the United Nations announced 17 sustainable...
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Sang Yup Lee

Visualizing Membrane Proteins Using X-ray and Electron

There are 1.7% coordinate files from membrane proteins deposited in the protein data bank. 20-30% of all ORFs genomic-wide are predicted to encode membrane proteins and more than 50% drug...
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Li Xiaodan

Understanding and Expanding the Photosynthetic Organisms for Terpenoid Production

Terpenoids are one of the largest classes of chemical compounds, some of them with industrial interest as nutraceuticals, biofuels, or chemical feedstock. Even though they are mainly plant-derived compounds, terpenoid...
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Konstantinos Vavitsas

Enzyme Functional Annotation: from new microbial metabolism to mammalian antiviral defense mechanisms

The vast majority of proteins have not been subjected to experimental functional annotation, and a large proportion are misannotated. We describe an integrated pipeline that supports high-throughput cloning, expression, purification,...
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Steven C. Almo

Tools and Strategies for Discovering Novel Enzymes in Novel Metabolic Pathways

The number of proteins in the UniProt database (>89M sequences in Release 2017_08) is increasing with a doubling time of 2.5 yrs; however, ≥50% of the proteins have uncertain or...
Read More
John A. Gerlt

An Overview of the Asian Office of Research and Development

The Asian Office of Research and Development (AOARD) oversees the U.S. Air Force’s R&D interests throughout the Asia-Pacific region. Located in Tokyo, AOARD is a field office of the Air...
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Jeremy Knopp
Jermont Chen

Southeast Asia in the Anthropocene: Can synthetic biology address conservation challenges?

The Anthropocene, the geological epoch we have entered, is named for the pervasive and novel impacts humans are having on the earth. Humans are breaching boundaries that have held throughout...
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Madhu Rao

Computation in Living Cells

Dr. Voigt will describe the development of the first language to program cells.  The function of electronic chips can be encoded in DNA and run by the cell.  This allows...
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Chris Voigt

The CRISPR revolution

CRISPR has become synonymous with disruptive genome-editing technologies that are revolutionizing basic research, biotechnology, medicine, and agriculture. One critical aspect of CRISPR often overlooked in this fanfare is that it...
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Chase Beisel

Credentials of Pseudomonas putida as a Real (not metaphoric) Cell Factory

Although bacterial cytoplasm is not compartmentalized this does not mean that cellular components are randomly organized or free to diffuse. Many studies have shown that proteins are located at particular...
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Victor de Lorenzo

DOE-ICL-NUS Foundry Technical Meeting

Synthetic Biology is the engineering of biology: synthesis of complex, biologically based (or inspired) systems which execute functions that do not exist in nature. Due to the inherent complexity of...
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The future outlook of 3D bioprinting is significant particularly in biomedicine for the creation of personalized medicine, drug screening, tissue replacement and future organ transplant. In the area of green...
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Mayasari Lim

Engineering an Expanded Chemical Palette in Cells

An industrial biotechnology revolution is approaching. Recent technical advances are leading to a rapid transformation of the chemical palette available in cells making it conceivable to produce nearly any organic...
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Hal Alper

The Seventh International Meeting on Synthetic Biology | SB7.0

About SB 7.0 The goal of SB7.0 is to unite again the international synthetic biology communities to take a fresh look at the key topics and challenges that our field...
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Nitric Oxide in Yeast: A Double-edged Sword “Cell Protection vs Cell Death”

Nitric oxide (NO) is a ubiquitous signaling molecule involved in the regulation of many cellular functions. The molecular function of NO in unicellular eukaryotic yeast is poorly understood due to...
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Hiroshi Takagi


SINERGY Seed Grant

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