Adenine Base Editors (ABEs), composed of the Cas9 nickase derived from S. pyogenes and engineered adenine deaminases derived from E. coli, enable efficient adenine-to-guanine single-nucleotide conversions in human cells.


Jin-Soo Kim is an entrepreneur and chemist-turned-biologist. He graduated from Seoul National University in 1987 with a major in chemistry. He then earned a master’s degree in chemistry from Seoul National University in 1989 and a Ph.D. in biochemistry from the University of Wisconsin-Madison in 1994. After postdoctoral training at Howard Hughes Medical Institute/Massachusetts Institute of Technology, he came back to Seoul in 1997 to serve as Principal Investigator at Samsung Biomedical Research Institute. He co-founded a biotechnology company, ToolGen, Inc., focused on zinc finger technology and genome editing in 1999, and served as CEO and CSO for the subsequent 6 years. He joined the faculty of the Department of Chemistry at Seoul National University in 2005 and now serves as Director of Center for Genome Engineering at Institute for Basic Science. He has published over 100 articles and filed 30 patent applications, mostly in the field of gene regulation and genome editing.

Throughout his independent scientific career since 1997, Jin-Soo Kim has been developing tools for genome editing, a method now used widely in biomedical research, biotechnology, and medicine. The broad interest in this rapidly evolving and expanding technology among researchers is highlighted by the choice of genome editing as Method of the Year 2011 by Nature Methods and Breakthrough of the Year 2015 by Science. Genome editing in cultured cells, animals, and plants is catalyzed by programmable nucleases that cleave chromosomal DNA in a targeted manner. The Kim group has developed and improved three different types of programmable nucleases, namely, zinc finger nucleases (ZFNs), TAL effector nucleases (TALENs), and RNA-guided endonucleases derived from CRISPR-Cas9 adaptive immune systems in prokaryotes. These tools are now used for genome editing in human stem cells, model organisms, livestock, and plants in thousands of labs all around the world.