Tools and Strategies for Discovering Novel Enzymes in Novel Metabolic Pathways
The number of proteins in the UniProt database (>89M sequences in Release 2017_08) is increasing with a doubling time of 2.5 yrs; however, ≥50% of... Read More
Enzyme Functional Annotation: from new microbial metabolism to mammalian antiviral defense mechanisms
The vast majority of proteins have not been subjected to experimental functional annotation, and a large proportion are misannotated. We describe an integrated pipeline that... Read More
