Sex Determination in Agricultural Pest Insects and Genetic Control Strategies

03 Jul 2020
18 February 2020 | 11.30am
CeLS Seminar Room 2

Sex Determination in Agricultural Pest Insects and Genetic Control Strategies

The dipteran Tephritidae family includes dozens of major agricultural pest species, including the mediterranean fruitfly Ceratitis capitata (medfly). The genetic control of these species can be based on the release of sterile males, following their sexing from females. A comparative evolutionary study of sex determining genes may open the way to achieve genetic sexing in different pest insects. We have isolated a Y-linked male determining gene of medfly, Maleness-on-the-Y (MoY), encoding a novel short protein, that is highly conserved in other species of this family, spanning 100 millions of years of evolution. Present challenges are to 1) understand MoY molecular mechanism of action in repressing the downstream female determining transformer gene by influencing its sex-specific splicing, and 2) develop MoY biotech usage to harness innovative genetic control strategies for Tephritidae invasive species.