Updates and Applications: Ambient Ionization Mass Spectrometry
Mass spectrometry (MS) is an important analytical technique with high sensitivity and selectivity. However, all known ambient MS ionization methods are significantly hindered by ion suppression that is caused by ion charge competition other than the target molecules. To eliminate this key problem without using chromatography and/or sample preparation which may be tedious and time consuming, current methods were developed through (i) integrating surface chemistry with ambient ionization source, (ii) developing a library of selective surfaces and (iii) integrating two or more ionization sources.
The key advantage of this innovation is that molecules of interest can be directly and rapidly sampled from complex mixtures without sample preparation/chromatography for detection by MS. It should prove beneficial for portable MS applications because relatively low detection limits can be obtained without the use of additional gadgets and can produce intact molecular ions.