Aberrant Stem/Progenitor Cell Behavior During Aging And Cancer
Adult stem cells, with the unique property of performing self-renewal and multi-lineage differentiation, are essential for maintaining homeostasis and function of various organs in our body, including the hematopoietic system and central nervous system. Aberrant stem cell behavior leads to disease as evidenced during aging (e.g. loss of regenerative potential and aberrant differentiation) and cancer (e.g. uncontrolled self-renewal activity, robust tumorigenic potential and therapeutic resistance), underscoring the importance of understanding the molecular pathways and processes governing whether stem cells pursue a path of cellular death/senescence hence aging versus one of deregulated growth and immortalization hence cancer. In this talk, I will present one of our current studies that establish a link between chromatin plasticity and tumor heterogeneity in cancer.